Spiro-oxindoles via bimetallic [Pd(0)/Ag(I)] catalytic intramolecular Heck-1,3-dipolar cycloaddition cascade reactions
2002; Elsevier BV; Volume: 43; Issue: 14 Linguagem: Inglês
10.1016/s0040-4039(02)00331-3
ISSN1873-3581
AutoresRonald Grigg, Emma L. Millington, Mark Thornton‐Pett,
Tópico(s)Catalytic Alkyne Reactions
ResumoAbstract The combination of an intramolecular Heck reaction with a subsequent Ag(I) catalysed imine→azomethine ylide→cycloaddition cascade is described for the formation of novel spiro-oxindoles. The reaction proceeds regiospecifically with good to excellent stereoselectivity and creates two new rings, three bonds and three stereocentres.
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