Non-phosgene synthesis of benzyl chloroformate (CbzCl)
2002; Elsevier BV; Volume: 43; Issue: 43 Linguagem: Inglês
10.1016/s0040-4039(02)01834-8
ISSN1873-3581
AutoresTakumi Mizuno, Junko Takahashi, Akiya Ogawa,
Tópico(s)Synthesis and Reactivity of Sulfur-Containing Compounds
ResumoA novel synthetic method for benzyl chloroformate (CbzCl) using carbon monoxide or carbonyl sulfide as a carbonyl source was established. Benzyl chloroformate was successfully synthesized by the chlorination using sulfuryl chloride of S-methyl O-benzyl carbonothioate, which was prepared by the carbonylation of benzyl alcohol with carbon monoxide and sulfur (or carbonyl sulfide) in the presence of DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) followed by esterification using methyl iodide.
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