Catalytic Batch and Continuous Flow Production of Highly Enantioenriched Cyclohexane Derivatives with Polymer-Supported Diarylprolinol Silyl Ethers
2011; Thieme Medical Publishers (Germany); Volume: 2011; Issue: 04 Linguagem: Inglês
10.1055/s-0030-1259528
ISSN1437-2096
AutoresMiquel À. Pericàs, Esther Alza, Sonia Sayalero, Xacobe C. Cambeiro, Rafael Martín‐Rapún, Pedro O. Miranda,
Tópico(s)Analytical Chemistry and Chromatography
ResumoDiarylprolinol silyl ethers immobilized onto polystyrene have been employed as catalysts in the enantioselective domino Michael-Knoevenagel reaction of dimethyl 3-oxoglutarate and 3-substituted acrolein derivatives, including aliphatic ones. The best catalyst allows the preparation of highly functionalized cyclohexane derivatives in a straightforward and efficient manner, both under batch and continuous flow conditions.
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