Artigo Revisado por pares

Synthesis of substituted quinolines by iron-catalyzed coupling reactions between chloroenynes and Grignard reagents

2004; Elsevier BV; Volume: 45; Issue: 9 Linguagem: Inglês

10.1016/j.tetlet.2004.01.019

ISSN

1873-3581

Autores

Matar Seck, Xavier Franck, Reynald Hocquemiller, Bruno Figadère, Jean‐François Peyrat, Olivier Provot, Jean‐Daniel Brion, Mouâd Alami,

Tópico(s)

Catalytic Alkyne Reactions

Resumo

This letter reports the preparation of quinolines, substituted at the 2- or 3-position by a 4-substituted but-3-en-1-yne group, by the environmentally friendly iron(III)-catalyzed coupling reaction of Grignard reagents with 1-chloro-4-(2-quinolyl)but-1-en-3-yne. The extension and the scope of this non-toxic and chemoselective procedure to various functionalized unsaturated vinyl chlorides are described.

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