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Synthesis of substituted quinolines by iron-catalyzed coupling reactions between chloroenynes and Grignard reagents

2004; Elsevier BV; Volume: 45; Issue: 9 Linguagem: Inglês

10.1016/j.tetlet.2004.01.019

1873-3581

Matar Seck, Xavier Franck, Reynald Hocquemiller, Bruno Figadère, Jean‐François Peyrat, Olivier Provot, Jean‐Daniel Brion, Mouâd Alami,

Catalytic Alkyne Reactions

This letter reports the preparation of quinolines, substituted at the 2- or 3-position by a 4-substituted but-3-en-1-yne group, by the environmentally friendly iron(III)-catalyzed coupling reaction of Grignard reagents with 1-chloro-4-(2-quinolyl)but-1-en-3-yne. The extension and the scope of this non-toxic and chemoselective procedure to various functionalized unsaturated vinyl chlorides are described.