The pixyl (Px) group: A novel photocleavable protecting group for primary alcohols
1998; Elsevier BV; Volume: 39; Issue: 13 Linguagem: Inglês
10.1016/s0040-4039(98)00013-6
ISSN1873-3581
Autores Tópico(s)Chemical Synthesis and Analysis
ResumoThe 9-phenylxanthyl (pixyl or Px) moiety has been investigated as a potential photocleavable protecting group for primary alcohols. Alcohols 2a-e were protected in good yield by treatment with 9-chloro-9-phenylxanthene in dry pyridine at room temperature. Irradiation of the alcohol derivatives in neutral aqueous acetonitrile regenerates 2a-e and the 9-phenylxanthyl alcohol.
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