Leptosins O-S, Cytotoxic Metabolites of a Strain of Leptosphaeria Sp. Isolated from a Marine Alga
2004; Elsevier BV; Volume: 63; Issue: 3 Linguagem: Inglês
10.3987/com-03-9967
ISSN1881-0942
AutoresTakeshi Yamada, Chika Iwamoto, Naoko Yamagaki, Takako Yamanouchi, Katsuhiko Minoura, Sanji Hagishita, Atsushi Numata,
Tópico(s)Bioactive Compounds and Antitumor Agents
ResumoLeptosins O (1), P (2), Q (3), R (4) and S (5) have been isolated from a strain of Leptosphaeria sp.originally separated from the marine alga Sargassum tortile.Their absolute stereostructures have been elucidated on the basis of spectroscopic analyses of their acetate derivatives (6-10) using various 1D and 2D NMR techniques and some chemical transformations.The NMR and NOE spectral analyses of 6-10 revealed that they exist in a single conformer of B type in CDCl 3 .Among these metabolites, leptosins O (1) and P (2) exhibited significant cytotoxicity against cultured P388 cells
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