Synthesis of β,β′-Diamino Acids from α-Amino Acid Derived β-Lactams
2008; Thieme Medical Publishers (Germany); Volume: 2008; Issue: 04 Linguagem: Inglês
10.1055/s-2008-1032079
ISSN1437-2096
AutoresJoachim Podlech, Alexander A. Taubinger, Dieter Fenske,
Tópico(s)Chemical Synthesis and Analysis
ResumoRing opening of protected 3-aminoalkyl-substituted azetidin-2-ones with O-, N-, or S-nucleophiles led to β,β′-diaminocarboxylic esters, amides, and thioesters, respectively. The reaction outcome is improved by addition of catalytic amounts of sodium azide. Reduction of the β-lactam amide moiety led to diamino alcohols.
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