Modified Pictet–Spengler reaction. A highly diastereoselective approach to 1,2,3-trisubstituted-1,2,3,4-tetrahydro-β-carbolines using perhydro-1,3-heterocycles
2001; Elsevier BV; Volume: 57; Issue: 37 Linguagem: Inglês
10.1016/s0040-4020(01)00763-3
ISSN1464-5416
AutoresKamaljit Singh, Prasant K. Deb, P. Venugopalan,
Tópico(s)Synthesis and pharmacology of benzodiazepine derivatives
ResumoA flexible variant of the Pictet–Spengler reaction employing oxazinanes as synthetic equivalents of several carbonyl compounds has been developed. Using acid catalyzed one pot condensation of perhydro-1,3-heterocycles various 1,3-disubstituted and 1,2,3-trisubstituted-1,2,3,4-tetrahydro-β-carbolines (THBCs) have been synthesized diastereoselectively.
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