Conversion of Marcfortine A to Paraherquamide A via Paraherquamide B. The First Formal Synthesis of Paraherquamide A
1997; American Chemical Society; Volume: 62; Issue: 6 Linguagem: Inglês
10.1021/jo9622791
ISSN1520-6904
AutoresByung Ho Lee, Michael F. Clothier,
Tópico(s)Chemical synthesis and alkaloids
ResumoThe paraherquamides and marcfortines represent a novel class of anthelmintics. The sole structural difference between paraherquamide A and marcfortine A occurs in ring G. We synthesized paraherquamide B from marcfortine A in six steps. Paraherquamide A was then prepared from paraherquamide B in seven steps. This represents the first formal synthesis of paraherquamide A.
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