Synthesis of 1-hydroxybicyclo[n.1.0]alkanes (n = 3 and 4) and their silyl ethers from olefinic esters via tandem intramolecular nucleophilic acyl substitution and intramolecular carbonyl addition reactions mediated by reagent
1996; Elsevier BV; Volume: 37; Issue: 11 Linguagem: Inglês
10.1016/0040-4039(96)00160-8
ISSN1873-3581
AutoresA. N. KASATKIN, Katsushige Kobayashi, Sentaro Okamoto, Fumie Sato,
Tópico(s)Asymmetric Hydrogenation and Catalysis
ResumoTreatment of olefinic esters with Ti(OPr-i)4/2 i-PrMgCl reagent resulted in intramolecular nucleophilic acyl substitution and successive intramolecular carbonyl addition reactions providing 1-hydroxybicyclo[n.1.0]alkanes (n = 3 and 4) in high yields.
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