Nitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Growth and Remodeling
2019; Wiley; Linguagem: Inglês
10.1002/cphy.c180026
ISSN2040-4603
AutoresSaranya Rajendran, Xinggui Shen, John Glawe, Gopi K. Kolluru, Christopher G. Kevil,
Tópico(s)Nitric Oxide and Endothelin Effects
ResumoNitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Growth and Remodeling Volume 9 Issue 3. July 2019 Saranya Rajendran, Saranya Rajendran Departments of Pathology, LSU Health Sciences Center, ShreveportSearch for more papers by this authorXinggui Shen, Xinggui Shen Departments of Pathology, LSU Health Sciences Center, ShreveportSearch for more papers by this authorJohn Glawe, John Glawe Departments of Pathology, LSU Health Sciences Center, ShreveportSearch for more papers by this authorGopi K. Kolluru, Gopi K. Kolluru Departments of Pathology, LSU Health Sciences Center, ShreveportSearch for more papers by this authorChristopher G. Kevil, Corresponding Author Christopher G. Kevil ckevil@lsuhsc.edu Departments of Pathology, LSU Health Sciences Center, Shreveport Departments of Cellular Biology and Anatomy, LSU Health Sciences Center, Shreveport Departments of Molecular and Cellular Physiology, LSU Health Sciences Center, ShreveportSearch for more papers by this author Saranya Rajendran, Saranya Rajendran Departments of Pathology, LSU Health Sciences Center, ShreveportSearch for more papers by this authorXinggui Shen, Xinggui Shen Departments of Pathology, LSU Health Sciences Center, ShreveportSearch for more papers by this authorJohn Glawe, John Glawe Departments of Pathology, LSU Health Sciences Center, ShreveportSearch for more papers by this authorGopi K. Kolluru, Gopi K. Kolluru Departments of Pathology, LSU Health Sciences Center, ShreveportSearch for more papers by this authorChristopher G. Kevil, Corresponding Author Christopher G. Kevil ckevil@lsuhsc.edu Departments of Pathology, LSU Health Sciences Center, Shreveport Departments of Cellular Biology and Anatomy, LSU Health Sciences Center, Shreveport Departments of Molecular and Cellular Physiology, LSU Health Sciences Center, ShreveportSearch for more papers by this author Published online: 12 June 2019 https://doi.org/10.1002/cphy.c180026Citations: 31 Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat ABSTRACT Ischemic vascular remodeling occurs in response to stenosis or arterial occlusion leading to a change in blood flow and tissue perfusion. Altered blood flow elicits a cascade of molecular and cellular physiological responses leading to vascular remodeling of the macro- and micro-circulation. Although cellular mechanisms of vascular remodeling such as arteriogenesis and angiogenesis have been studied, therapeutic approaches in these areas have had limited success due to the complexity and heterogeneous constellation of molecular signaling events regulating these processes. Understanding central molecular players of vascular remodeling should lead to a deeper understanding of this response and aid in the development of novel therapeutic strategies. Hydrogen sulfide (H2S) and nitric oxide (NO) are gaseous signaling molecules that are critically involved in regulating fundamental biochemical and molecular responses necessary for vascular growth and remodeling. This review examines how NO and H2S regulate pathophysiological mechanisms of angiogenesis and arteriogenesis, along with important chemical and experimental considerations revealed thus far. The importance of NO and H2S bioavailability, their synthesis enzymes and cofactors, and genetic variations associated with cardiovascular risk factors suggest that they serve as pivotal regulators of vascular remodeling responses. © 2019 American Physiological Society. Compr Physiol 9:1213-1247, 2019. Citing Literature Comprehensive PhysiologyBrowse other articles of this reference work:BROWSE TABLE OF CONTENTSBROWSE BY TOPICBROWSE A-Z RelatedInformation
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