α,β-Differentiated tandem diamination of cinnamic esters using N,N-dichloro-2-nitrobenzenesulfonamide and acetonitrile as the nitrogen sources
2000; Elsevier BV; Volume: 41; Issue: 45 Linguagem: Inglês
10.1016/s0040-4039(00)01579-3
ISSN1873-3581
AutoresGuigen Li, Sun Hee Kim, Han‐Xun Wei,
Tópico(s)Catalytic C–H Functionalization Methods
ResumoTandem diamination of cinnamic esters provides a new approach to anti alkyl Nα-(2-Ns), Nβ-Ac diaminophenylpropionates. The new reaction proceeds to completion within 3 hours at room temperature using N,N-dichloro-2-nitrobenzenesulfonamide (2-NsNCl2) as the nitrogen source in acetonitrile, which is also involved in the reaction process. Seven diamine derivatives have been obtained with good yields and stereoselectivity.
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