Total Synthesis of Siastatin B and Its Enantiomer Using Carbohydrate as a Chiral Educt
1992; Oxford University Press; Volume: 65; Issue: 4 Linguagem: Inglês
10.1246/bcsj.65.978
ISSN1348-0634
AutoresYoshio Nishimura, When-mei Wang, Toshiaki Kudo, Shinichi Kondo,
Tópico(s)Microbial Natural Products and Biosynthesis
ResumoThe enantioselective synthesis of siastatin B, an inhibitor of neuraminidase and its antipode from D-ribono-γ-lactone has stereospecifically been achieved. The total synthesis elucidated the absolute configuration of siastatin B as (3S,4S,5R,6R)-6-acetamido-4,5-dihydroxy-3-piperidinecarboxylic acid.
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