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Toxoplasma Controls Host Cyclin E Expression through the Use of a Novel MYR1-Dependent Effector Protein, HCE1

2019; American Society for Microbiology; Volume: 10; Issue: 2 Linguagem: Inglês

10.1128/mbio.00674-19

2161-2129

Michael W. Panas, Adit Naor, Alicja M. Cygan, John C. Boothroyd,

interferon and immune responses

is an obligate intracellular parasite that establishes a favorable environment in the host cells in which it replicates. We have previously reported that it uses MYR-dependent translocation of dense granule proteins to elicit a key set of host responses related to the cell cycle, specifically, E2F transcription factor targets, including cyclin E. We report here the identification of a novel