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Synthesis of N -Glycosylated Pyridines as New Antiviral Agents

1995; Taylor & Francis; Volume: 14; Issue: 6 Linguagem: Inglês

10.1080/15257779508010701

2332-3892

E.‐S. A. IBRAHIM, Galal H. Elgemeie, M. M. ABBASI, Youssef A. Abbas, Mahmoud A. El‐Badawi, Adel M. Attia,

HIV Research and Treatment

Abstract A series of 3-cyanopyridine glycosides have been synthesized and evaluated for their inhibitory activity against human immunodeficiency virus (HIV) replication in MT-4 cells. Among the 3-cyanopyridine glycosides 6-(p-methylphenyl) and 6-(p-aminophenyl) were the most selective inhibitors of HIV replication.