Stereoselective additions of grignard reagents to masked imines and iminium ions
1996; Elsevier BV; Volume: 37; Issue: 48 Linguagem: Inglês
10.1016/s0040-4039(96)02013-8
ISSN1873-3581
AutoresMichel Bortolussi, Christophe Cinquin, Robert J. Bloch,
Tópico(s)Advanced Synthetic Organic Chemistry
ResumoAdditions of organomagnesium bromides to the masked imine 2 or iminium ion 3 were found to be highly diastereoselective, and were shown to occur on the same diastereotopic face of the CN bonds of these two compounds. Thermolysis of the aminoalcohols obtained gave rise to chiral allylic aminoalcohols of high synthetic potential.
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