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Neurotrophic Keratopathy

2019; Elsevier BV; Volume: 4; Linguagem: Inglês

10.1016/j.yaoo.2019.05.003

2452-1760

Krishi Peddada, B. Campbell, Briana Ply, An Vo,

Corneal surgery and disorders

Neurotrophic keratopathy (NK) was first described in 1824, with the observation that transection of the trigeminal nerve leads to degenerative changes in the cornea [1]. These corneal changes are secondary to altered cellular metabolism, which leads to accumulation of metabolites and subsequent tissue swelling, loss of vitality, and desquamation [2]. Reduction in corneal sensitivity or complete corneal anesthesia is the hallmark of NK and can lead to epithelial keratopathy, ulceration, and perforation [3].