A simple method for the alkaline hydrolysis of esters
2007; Elsevier BV; Volume: 48; Issue: 46 Linguagem: Inglês
10.1016/j.tetlet.2007.09.074
ISSN1873-3581
AutoresVassiliki Theodorou, Konstantinos Skobridis, Andreas G. Tzakos, Valentine Ragoussis,
Tópico(s)Innovative Microfluidic and Catalytic Techniques Innovation
ResumoA very mild and rapid procedure for the efficient alkaline hydrolysis of esters in non-aqueous conditions has been developed, by the use of dichloromethane/methanol (9:1) as solvent. This method conveniently provides both carboxylic acids and alcohols from the corresponding esters and sodium hydroxide in a few minutes at room temperature. A plausible reaction mechanism is proposed.
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