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Investigations into the Bromination of Substituted Phenols using Diethyl Bromomalonate and Diethyl Dibromomalonate

2001; Oxford University Press; Volume: 74; Issue: 1 Linguagem: Inglês

10.1246/bcsj.74.179

1348-0634

Gregory S. Coumbarides, Marco Dingjan, Jason Eames, Neluka Weerasooriya,

Environmental and Industrial Safety

Abstract Substituted 4-bromophenols can be synthesised efficiently by heating the corresponding phenol in either neat diethyl bromomalonate or diethyl dibromomalonate. We discuss the regioselectivity of such reactions and comment on the scope and limitation of this procedure.