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Preparation of α-Halo-α,β-Unsaturated Bicyclic Lactams and Their Use in Palladium-Catalyzed Cross Coupling Reactions

1993; Thieme Medical Publishers (Germany); Volume: 1993; Issue: 08 Linguagem: Inglês

10.1055/s-1993-22533

1437-2096

Bradley J. Newhouse, A. I. Meyers, Nilantha Sirisoma, Matthew P. Braun, Carl R. Johnson,

Cyclopropane Reaction Mechanisms

Efficient syntheses of α-halo-α,β-unsaturated lactams from the corresponding saturated and unsaturated lactams are described. These substrates undergo palladium-catalyzed Stille and Suzuki couplings, furnishing α-substituted-α,β-unsaturated lactams in good yields.