Dianion Approach to Chiral Cyclopropene Carboxylic Acids
2004; American Chemical Society; Volume: 6; Issue: 26 Linguagem: Inglês
10.1021/ol047837+
ISSN1523-7060
AutoresLian‐an Liao, Ni Yan, Joseph M. Fox,
Tópico(s)Asymmetric Synthesis and Catalysis
Resumo[reaction: see text] In this Letter, we describe a general method for preparing the dianions of cyclopropene carboxylic acids, and we show that their subsequent reactions with electrophiles provide a general means for selectively introducing diverse types of functional groups. This provides a general method for the synthesis of chiral 1,2-disubstituted cyclopropenes, and opens new avenues for the enantioselective preparation of cyclopropenes.
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