Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Evolutionary genomic dynamics of Peruvians before, during, and after the Inca Empire

2018; National Academy of Sciences; Volume: 115; Issue: 28 Linguagem: Inglês

10.1073/pnas.1720798115

1091-6490

Daniel Harris, Wei Song, Amol C. Shetty, Kelly S. Levano, Omar Cáceres, Carlos Padilla, Víctor Borda, David Tarazona, Omar Trujillo, César Sánchez, Michael D. Kessler, Marco Galarza, Silvia Capristano, Harrison Montejo, Pedro O. Flores-Villanueva, Eduardo Tarazona‐Santos, Timothy D. O’Connor, Heinner Guio,

Genetic diversity and population structure

Significance Through the Peruvian Genome Project we generate and analyze the genomes of 280 individuals where the majority have >90% Native American ancestry and explore questions at the interface of evolutionary genetics, history, anthropology, and medicine. This is the most extensive sampling of high-coverage Native American and mestizo whole genomes to date. We estimate an initial peopling of Peru was rapid and began by 12,000 y ago. In addition, the mestizo populations exhibit admixture between Native American groups prior to their Spanish admixture and was likely influenced by the Inca Empire and Spanish conquest. Our results address important Native American population history questions and establish a dataset beneficial to address the underrepresentation of Native American ancestry in sequencing studies.