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Asymmetric Total Synthesis of (+)-Fostriecin

2002; American Chemical Society; Volume: 4; Issue: 6 Linguagem: Inglês

10.1021/ol025537r

1523-7060

Y. Krishna Reddy, John R. Falck,

Carbohydrate Chemistry and Synthesis

The title compound, a potent protein phosphatase inhibitor and anticancer agent, was prepared by an efficient, multiconvergent asymmetric synthesis. Key transformations include a ring forming olefin metathesis leading to the α,β-unsaturated lactone and creation of the triene moiety via Suzuki cross-coupling.