Voltar
Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Marginal Effects of Systemic CCR5 Blockade with Maraviroc on Oral Simian Immunodeficiency Virus Transmission to Infant Macaques

2018; American Society for Microbiology; Volume: 92; Issue: 17 Linguagem: Inglês

10.1128/jvi.00576-18

ISSN

1098-5514

Autores

Egidio Brocca‐Cofano, Cuiling Xu, Katherine S. Wetzel, Mackenzie L. Cottrell, Benjamin B. Policicchio, Kevin D. Raehtz, Dongzhu Ma, Tammy Dunsmore, George S. Haret-Richter, Karam Musaitif, Brandon F. Keele, Angela D. M. Kashuba, Ronald G. Collman, Ivona Pandrea, Cristian Apetrei,

Tópico(s)

HIV/AIDS drug development and treatment

Resumo

Current approaches do not eliminate all human immunodeficiency virus type 1 (HIV-1) maternal-to-infant transmissions (MTIT); new prevention paradigms might help avert new infections. We administered maraviroc (MVC) to rhesus macaques (RMs) to block CCR5-mediated entry, followed by repeated oral exposure of a CCR5-dependent clone of simian immunodeficiency virus (SIV) mac251 (SIVmac766). MVC significantly blocked the CCR5 coreceptor in peripheral blood mononuclear cells and tissue cells. All control animals and 60% of MVC-treated infant RMs became infected by the 6th challenge, with no significant difference between the number of exposures (

Referência(s)