Synthesis of hexahydro-1H-pyrrolo[1,2-c]imidazole derivatives by sequential azomethine ylide cycloaddition and urea cyclization reactions
1998; Elsevier BV; Volume: 39; Issue: 13 Linguagem: Inglês
10.1016/s0040-4039(98)00125-7
ISSN1873-3581
AutoresSamir Najdi, Ki Hun Park, Marilyn M. Olmstead, Mark J. Kurth,
Tópico(s)Cyclopropane Reaction Mechanisms
ResumoAbstract An efficient, diastereoselective route to 2, 5, 6, 7-tetra-substituted 1H-purrolo[1,2-c]imidazoles has been developed using azomethine ylide cycloaddition and urea cyclization reactions. Relative stereochemical assignments at the four contiguous pyrrolidine stereogenic centers were established by single-crystal X-ray analysis.
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