Silane-Promoted Cycloisomerization of Functionalized 1,6-Dienes Catalyzed by a Cationic (π-Allyl)palladium Complex
1999; American Chemical Society; Volume: 1; Issue: 7 Linguagem: Inglês
10.1021/ol9908981
ISSN1523-7060
AutoresRoss A. Widenhoefer, Nicholas S. Perch,
Tópico(s)Synthetic Organic Chemistry Methods
ResumoA 1:1 mixture of the (π-allyl)palladium complex (η3-C3H5)Pd(Cl)PCy3 and NaB[3,5-C6H3(CF3)2]4 in the presence of HSiEt3 catalyzed the cycloisomerization of functionalized 1,6-dienes to form 1,2-disubstituted cyclopentenes in good yield with high selectivity (typically >94%). The protocol tolerated a range of functional groups and substitution at one of the allylic carbon atoms.
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