New Diffusion-Edited NMR Experiments To Expedite the Dereplication of Known Compounds from Natural Product Mixtures
2000; American Chemical Society; Volume: 2; Issue: 3 Linguagem: Inglês
10.1021/ol991239r
ISSN1523-7060
AutoresR. Thomas Williamson, Eleanor L. Chapin, Andy W. Carr, Jeffrey R. Gilbert, Paul R. Graupner, Paul Lewer, Pat McKamey, John R. Carney, William H. Gerwick,
Tópico(s)Advanced NMR Techniques and Applications
Resumo[reaction: see text] We present two new diffusion-edited NMR experiments, improved DECODES and HETDECODES, that sort the constituents in a mixture by their individual diffusion coefficients. These experiments should allow the partial NMR spectral assignment and cursory structure elucidation of compounds in a complex mixture as an aid in the dereplication of known or nuisance compounds.
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