Modified nucleosides. A general and diastereoselective approach to N,O-psiconucleosides
2002; Elsevier BV; Volume: 58; Issue: 3 Linguagem: Inglês
10.1016/s0040-4020(01)01161-9
ISSN1464-5416
AutoresDaniela Iannazzo, Anna Piperno, Venerando Pistarà, Antonio Rescifina, Roberto Romeo,
Tópico(s)Carbohydrate Chemistry and Synthesis
ResumoAn efficient reaction route towards the new class of N,O-psiconucleosides has been designed, based on the 1,3-dipolar cycloaddition of C-[(tert-butyldiphenylsilyl)oxy]methyl-N-methyl nitrone with ethyl 2-acetyloxyacrylate, followed by nucleosidation. The process has been successfully applied to all pyrimidine and purine nucleobases.
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