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Association of Prognostic Nutritional Index as a predictive factor of survival in patients with colorectal cancer in a Mexican population

2019; Elsevier BV; Volume: 30; Linguagem: Inglês

10.1093/annonc/mdz155.342

1569-8041

C. Díaz, G. Calderillo-Ruiz, Maritza Ramos-Ramírez, Marytere Herrera, Felipe A. Calvo, L. Horacio, Érika Ruiz-García, V. Itzel, Javier Melchor Ruan, Gus Miranda, Ángel Herrera‐Gómez, Abelardo Meneses,

Colorectal and Anal Carcinomas

Introduction: The prognostic nutritional index (PNI), which is calculated based on the serum albumin concentration and peripheral blood lymphocyte count. The preoperative nutritional and immunological statuses have an important impact in predicting the survival outcome of patients with various types of malignant tumors. However, few studies have investigated PNI in colorectal cancer. We evaluated the ability and clinical significance of PNI to predict outcomes in patients with colorectal cancer. Methods: This retrospective study included a total of 702 patients diagnosed with colorectal cancer who received treatment at the National Cancer Institute between the period 2011-2013. The PNI level was determined according to the following formula: 10× serum albumin (g/dL)+0.005×total lymphocyte count (per mm3). The impact of PNI on clinicopathological features and overall survival (OS) at two years was determined. The optimal cutoff value of PNI was set at 40 according to ROC curve. Results: 52% (365) represent men and 48% women (337) women, 45 years 73.1% (514). Patients with colon cancer 48.2% (339), rectal cancer 51.8% (363). In relation to the degree of differentiation Well differentiated 26.2% (183), moderately differentiated 56.5% (397), poorly differentiated 14.3% (101), Not determined 3% (21). Presence of liver metastases 39.2% (269). The survival analysis with a following two years was for low PNI < 40 was 21.8% and high PNI >40 was 78.2% respectively. IC = 0.6 (0.43 to 0.97) p = 0.03. Patients in the low-PNI group had a greater potential to have aggressive histological features, advanced tumors (T), nodal involvement (N) and TNM stage than those in the high-PNI group. Conclusion: Patients with colorectal cancer with IPN high > 40 have a better overall life compared to those with an IPN < 40. The IPN analysis is a simple and useful marker to predict clinicopathological features and long-term survival outcome in patients with colorectal carcinoma. PNI analysis should be included in the routine assessment of patients with colorectal cancer, and prospective validation is required.