Produção Nacional
Revisado por pares
Origanum vulgare L. essential oil inhibits the growth of carbapenem-resistant gram-negative bacteria
2019; Brazilian Society of Tropical Medicine; Volume: 52; Linguagem: Inglês
10.1590/0037-8682-0502-2018
ISSN1678-9849
AutoresNathalie Gaebler Vasconcelos, Júlio Croda, Késia Esther Silva, Maria Lorenza Leal Motta, Wirlaine Glauce Maciel, Letícia Cristina Limiere, Simone Simionatto,
Tópico(s)Pharmacological Effects of Natural Compounds
ResumoPlant products are sources for drug development against multidrug resistant bacteria.The antimicrobial activity of Origanum vulgare L. essential oil (OVeo) against carbapenem-resistant strains was assessed by disk-diffusion, microdilution (REMA-Resazurin Microtiter Assay), and time kill assays.Carbapenemase production was confirmed for all strains. OVeo exhibited a minimum inhibitory concentration of 0.059% v/v for Klebsiella pneumoniae and Serratia marcescens, and of 0.015 % v/v for Acinetobacter baumannii. A decrease in cell count was observed after a 4 h treatment.OVeo antimicrobial effect was rapid and consistent, making it a candidate for developing alternative therapeutic options against carbapenem-resistant strains.
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