Dysfunctional stem and progenitor cells impair fracture healing with age
2019; Baishideng Publishing Group; Volume: 11; Issue: 6 Linguagem: Inglês
10.4252/wjsc.v11.i6.281
ISSN1948-0210
AutoresDiane R. Wagner, Sonali Karnik, Zachary J. Gunderson, Jeffery J. Nielsen, Alanna Fennimore, Hunter J Promer, Jonathan W. Lowery, M. Terry Loghmani, Philip S. Low, Todd O. McKinley, Melissa A. Kacena, Matthias Clauss, Jiliang Li,
Tópico(s)Bone and Joint Diseases
ResumoSuccessful fracture healing requires the simultaneous regeneration of both the bone and vasculature; mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site.In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells.MSCs from older individuals are impaired with regard to cell WJSC https://www.wjgnet.com
Referência(s)