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Clinical translation of FLASH radiotherapy: Why and how?

2019; Elsevier BV; Volume: 139; Linguagem: Inglês

10.1016/j.radonc.2019.04.008

1879-0887

Jean Bourhis, Pierre Montay‐Gruel, Patrik Gonçalves Jorge, Claude Bailat, Benoît Petit, Jonathan Ollivier, Wendy Jeanneret‐Sozzi, Mahmut Özşahin, François Bochud, Raphaël Moeckli, Jean‐François Germond, Marie‐Catherine Vozenin,

Effects of Radiation Exposure

Over the past decades, technological advances have transformed radiation therapy (RT) into a precise and powerful treatment for cancer patients. Nevertheless, the treatment of radiation-resistant tumors is still restricted by the dose-limiting normal tissue complications. In this context, FLASH-RT is emerging in the field. Consisting of delivering doses within an extremely short irradiation time, FLASH-RT has been identified as a promising new tool to enhance the differential effect between tumors and normal tissues. Indeed, preclinical studies on various animal models and a veterinarian clinical trial have recently shown that compared to conventional dose-rate RT, FLASH-RT could control tumors while minimizing normal tissue toxicity. In the present review, we summarize the main data supporting the clinical translation of FLASH-RT and explore its feasibility, the key irradiation parameters and the potential technologies needed for a successful clinical translation.