Epistasis between antibiotic tolerance, persistence, and resistance mutations
2019; National Academy of Sciences; Volume: 116; Issue: 29 Linguagem: Inglês
10.1073/pnas.1906169116
ISSN1091-6490
AutoresIrit Levin-Reisman, Asher Brauner, Irine Ronin, Nathalie Q. Balaban,
Tópico(s)Bacterial Genetics and Biotechnology
ResumoUnderstanding the evolution of microorganisms under antibiotic treatments is a burning issue. Typically, several resistance mutations can accumulate under antibiotic treatment, and the way in which resistance mutations interact, i.e., epistasis, has been extensively studied. We recently showed that the evolution of antibiotic resistance in
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