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BIBTEX RIS

Exploring the Role of Staphylococcus Aureus Toxins in Atopic Dermatitis

2019; Multidisciplinary Digital Publishing Institute; Volume: 11; Issue: 6 Linguagem: Inglês

10.3390/toxins11060321

ISSN

2072-6651

Autores

Fábio Seiti Yamada Yoshikawa, Josenilson Feitosa de Lima, Maria Notomi Sato, Yasmin Álefe Leuzzi Ramos, Valéria Aoki, Raquel Leão Orfali,

Tópico(s)

Herbal Medicine Research Studies

Resumo

Atopic dermatitis (AD) is a chronic and inflammatory skin disease with intense pruritus and xerosis. AD pathogenesis is multifactorial, involving genetic, environmental, and immunological factors, including the participation of Staphylococcus aureus. This bacterium colonizes up to 30-100% of AD skin and its virulence factors are responsible for its pathogenicity and antimicrobial survival. This is a concise review of S. aureus superantigen-activated signaling pathways, highlighting their involvement in AD pathogenesis, with an emphasis on skin barrier disruption, innate and adaptive immunity dysfunction, and microbiome alterations. A better understanding of the combined mechanisms of AD pathogenesis may enhance the development of future targeted therapies for this complex disease.

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