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Cytotoxic Lesions of the Corpus Callosum Caused by Thermogenic Dietary Supplements

2019; American Society of Neuroradiology; Volume: 40; Issue: 8 Linguagem: Inglês

10.3174/ajnr.a6116

1936-959X

Javier Andrés Galnares‐Olalde, Aldo J. Vázquez Mézquita, Gilberto Gómez-Garza, D. Reyes-Vázquez, V. Higuera-Ortiz, Marco Antonio Alegría‐Loyola, Alfredo Méndez-Domínguez,

RNA regulation and disease

SUMMARY: Consumption of over-the-counter dietary supplements to reduce body weight is common among the population. Thermogenics are herbal combinations that claim to produce a fat-burning process through an increase in the cellular metabolic rate and greater cellular energy consumption, having a high risk for patients developing toxic leukoencephalopathy. We present a series of 6 patients with acute neurologic symptoms and MR imaging showing restricted diffusion and decreased apparent diffusion coefficient values (mean value, 400 mm 2 /s × 10 −6 ) in the entire corpus callosum compatible with a cytotoxic lesion of the corpus callosum. Although patients responded favorably to the product discontinuation with rapid recovery of neurologic symptoms, there was a more prolonged resolution on imaging alterations. Because of the widespread availability and unregulated nature of thermogenic dietary supplements, physicians must be aware of the clinical and radiologic characteristics of these potential complications of their use.