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PCN171 OVARIAN CANCER IN KAZAKHSTAN: TRENDS IN AGE-STANDARDISED INCIDENCE AND MORTALITY RATES.

2019; Elsevier BV; Volume: 22; Linguagem: Inglês

10.1016/j.jval.2019.04.293

1524-4733

Çisem Bektur, Zaure Dushimova, Dilyara Kaidarova, MW Pennington,

Ovarian cancer diagnosis and treatment

To determine the epidemiological statistics of ovarian cancer (OC) in Kazakhstan and to analyse trends and variations in incidence and mortality by age and region. National OC registry data from 2016-2017 was analysed using STATA (version 15.1; StataCorp LLC, Texas, USA). Differences in the age profile of regions have been adjusted through age-standardising the incidence and mortality rates by direct method using WHO world standard population estimates. Age-standardised incidence rate remained stable in 2016-2017 at around 9.5 per 100 000 female population. Rates vary from 8.12 (Aqmola region) to 14.65 (Astana city) per 100 000 female population. There is evidence that rates are lower than the national average for residents of two regions (Aqmola region (p≤0.025), Almaty region (p≤0.025)), and higher for residents of four regions, including the capital (North-Kazakhstan region (p≤0.025), Karagandy region (p≤0.001), West-Kazakhstan region (p≤0.001), and Astana city (p≤0.001)). According to the 2017 data, the age-specific incidence rates grow steadily with age, peaking among women in the age groups 60-64 and 75-79. Age-standardised mortality rate remained stable in 2016-2017 at around 3.8 per 100 000 female population. Rates vary from 1.48 (Kostanay region) to 4.96 (West-Kazakhstan region) per 100 000 female population. There is evidence that rates are lower than the national average for residents of three regions (Almaty city (p≤0.025), Almaty region (p≤0.001), and Kostanay region (p≤0.001)), and higher for residents of five regions (North-Kazakhstan region (p≤0.025), Karagandy region (p≤0.025), Pavlodar region (p≤0.025), Qyzylorda region (p≤0.025), and West-Kazakhstan region (p≤0.001)). In 2016-2017, the age-specific mortality rate sharply increased with age from 40-44 age group onward. This registry analysis of OC in Kazakhstan is the first of its kind, providing comprehensive estimates of age-standardised incidence and mortality rates that lay a foundation for future research in Central Asia.