Plasma Hepatitis E Virus Kinetics in Solid Organ Transplant Patients Receiving Ribavirin
2019; Multidisciplinary Digital Publishing Institute; Volume: 11; Issue: 7 Linguagem: Inglês
10.3390/v11070630
ISSN1999-4915
AutoresSébastien Lhomme, Swati DebRoy, Nassim Kamar, Florence Abravanel, David Metsu, Olivier Marion, Chloé Dimeglio, Scott J. Cotler, Jacques Izopet, Harel Dahari,
Tópico(s)Viral gastroenteritis research and epidemiology
ResumoHepatitis E virus (HEV) infection causes chronic hepatitis in solid organ transplant (SOT) recipients. Antiviral therapy consists of three months of ribavirin, although response rates are not optimal. We characterized plasma HEV kinetic patterns in 41 SOT patients during ribavirin therapy. After a median pharmacological delay of three (range: 0-21) days, plasma HEV declined from a median baseline level of 6.12 (3.53-7.45) log copies/mL in four viral kinetic patterns: (i) monophasic (
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