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Association of polymorphisms in NFκB1 promoter and NFκBIA gene with the development of antibodies against HHV-8 in HIV-infected individuals

2019; Elsevier BV; Volume: 535; Linguagem: Inglês

10.1016/j.virol.2019.07.011

1096-0341

Juliana Prado Gonçales, José Valter Joaquim Silva Júnior, Thaísa Regina Rocha Lopes, Tânia Regina Tozetto‐Mendoza, Deborah de Farias Guimarães, Viviane Martha Santos de Morais, Maria Rosângela Cunha Duarte Coêlho,

Lymphoma Diagnosis and Treatment

Human gammaherpesvirus 8 (HHV-8) is the etiologic agent of Kaposi's sarcoma, multicentric Castleman's disease and primary effusion lymphoma. Like other herpesviruses, the HHV-8 may exhibit latent or lytic cycle, both regulated by viral and host factors. Regarding host factors, we analysed the association of polymorphisms in NFkB1 promoter (NFkB1-94 ins/del ATTG) and NFκBIA gene (NFκBIA 3′UTR A→G) with the development of antibodies against latent or lytic antigens from HHV-8. The ins/del [OR 7.9 (95% CI 3.3–19.1), p < 0.001], AG [OR 12.3 (95% CI 4.3–34.9) p < 0.001], GG [OR 9.4 (95% CI 3.2–27.9), p < 0.001], ins/del + AG [OR 94.5 (95% CI 9.6–924.4), <0.0001], ins/del + GG [OR 50.4 (95% CI 5.2–482.2, p < 0.0001] and G allele [OR 3.3 (95% CI 2.0–5.6), p < 0.001] were strongly related with the presence of antibodies to lytic antigens. This is the first association of polymorphisms in NFκB1 promoter and NFκBIA gene with the development of antibodies against HHV-8.