Dysregulation of the endothelial nitric oxide pathway is associated with airway inflammation in COPD
2019; BioMed Central; Volume: 20; Issue: 1 Linguagem: Inglês
10.1186/s12931-019-1133-8
ISSN1465-993X
AutoresBalázs Csoma, András Bikov, Lajos Nagy, Bence Tóth, Tamás Tábi, Gergő Szűcs, Zsolt István Komlósi, Veronika Müller, György Losonczy, Zsófia Lázár,
Tópico(s)Neuroscience of respiration and sleep
ResumoChronic obstructive pulmonary disease (COPD) is related to endothelial dysfunction and the impaired generation of nitric oxide (NO) from L-arginine by the endothelial NO synthase (eNOS). The relationship between eNOS dysfunctionality and airway inflammation is unknown. We assessed serum asymmetric and symmetric dimethylarginine (ADMA and SDMA) and nitrite/nitrate concentrations, indicators of eNOS function, in patients with COPD and correlated them with markers of inflammation.
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