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BIBTEX RIS

Experimental evidences that P21 protein controls Trypanosoma cruzi replication and modulates the pathogenesis of infection

2019; Elsevier BV; Volume: 135; Linguagem: Inglês

10.1016/j.micpath.2019.103618

1096-1208

Thaíse Lara Teixeira, Patrícia de Castilhos, Cassiano Costa Rodrigues, Aline A. da Silva, Rebecca T. S. Brígido, Samuel Cota Teixeira, Bruna Cristina Borges, Marlus Alves dos Santos, Flávia Alves Martins, Paulo C. F. dos Santos, João Paulo Silva Servato, M.S. Silva, M.J.B. da Silva, Maria Carolina Elias, Cláudio Vieira da Silva,

Signaling Pathways in Disease

P21 is a protein secreted by Trypanosoma cruzi (T. cruzi). Previous studies have shown a spectrum of biological activities performed by P21 such as induction of phagocytosis, leukocyte chemotaxis and inhibition of angiogenesis. However, the activity of P21 in T. cruzi infection remains unknown. Here, we reported the role of P21 in mice harboring late T. cruzi infection. Treatment with recombinant P21 protein (rP21) reduced parasite load and angiogenesis, and induced fibrosis in the cardiac tissue of infected mice. In addition, rP21 reduced the growth of epimastigotes, inhibited intracellular replication of amastigotes and modulated the parasite cell cycle. Our data suggest that P21 controls parasite replication in the host, supporting the survival of both parasite and host.