Total Motile Sperm Count Trend Over Time: Evaluation of Semen Analyses From 119,972 Men From Subfertile Couples
2019; Elsevier BV; Volume: 132; Linguagem: Inglês
10.1016/j.urology.2019.06.038
ISSN1527-9995
AutoresAshley W. Tiegs, J. Landis, Nicolás Garrido, Richard T. Scott, James M. Hotaling,
Tópico(s)Ovarian function and disorders
ResumoObjective To determine whether a clinically-relevant change in the total motile sperm count (TMSC) over time exists within the subfertile population. Methods The first semen analysis of all men presenting to selected infertility centers in 2 countries between 2002 and 2017 were evaluated. Semen analyses were categorized into 3 clinically-relevant groups based on treatment options: TMSC >15 million (M) (Group 1), in which no insemination intervention would be required; TMSC 5-15 M (Group 2), in which intrauterine insemination would be appropriate; and TMSC of 15 M) was found to decline approximately 10 percentage points over the past 16 years in the analysis of combined centers (odds ratio 0.967; 95% confidence interval = 0.963-0.971; P = 2.2e-16). A reciprocal increase was distributed between both the moderate (5-15 M) and severe (<5 M) oligozoospermia groups. Additionally, TMSC declined 1.1 percentage points with each year of advancing paternal age. No difference was seen in age at presentation by year. Conclusion The proportion of men with normozoospermia declined and that of men at risk of requiring fertility treatment increased over the study time period. Although several unknown factors may have influenced our data as a result of the retrospective design, a shift in treatment group membership over time may be clinically relevant.
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