Portal de Periódicos da CAPES

Renal prostaglandins E 2 and F 2α throughout normal human pregnancy

1986; Wiley; Volume: 16; Issue: 2 Linguagem: Inglês

10.1111/j.1365-2362.1986.tb01317.x

1365-2362

J. Bernheim, J. Shapira, F David, C. BEHARI, I. GELERNTNER, M. Rathaus,

Electrolyte and hormonal disorders

Abstract. Twenty‐five normal pregnant women were studied sequentially at 4‐week intervals, beginning from weeks 8–16 until delivery. In eighteen women the study was repeated 6 weeks after delivery. The 24‐h urinary excretion of PGE 2 and PGF 2α plasma renin activity (PRA), plasma aldosterone and fractional excretion of sodium (FE Na ) were measured at each visit. PGE 2 and PGF 2α , increased progressively throughout pregnancy (867 ± 81 and 1048 ± 94 ng 24 h ‐1 respectively, before week 15 and 1581 ± 175 and 2625 ± 305 ng 24 h ‐1 , respectively, after week 35) and returned to normal values 6 weeks after delivery (748 ± 107 and 1503 ± 165 ng 24 h ‐1 , respectively). PRA and aldosterone increased in a similar fashion, but values of prostaglandins did not correlate with those of PRA or aldosterone. PGE 2 correlated directly with FE Na but this correlation was weak. These results may suggest that tubulo‐interstitial prostaglandins play a role in the regulation of sodium homeostasis during pregnancy.