Iranome: A catalog of genomic variations in the Iranian population
2019; Wiley; Volume: 40; Issue: 11 Linguagem: Inglês
10.1002/humu.23880
ISSN1098-1004
AutoresZohreh Fattahi, Maryam Beheshtian, Marzieh Mohseni, Hossein Poustchi, Erin Sellars, Sayyed Hossein Nezhadi, Amir Amini, Sanaz Arzhangi, Khadijeh Jalalvand, Peyman Jamali, Zahra Mohammadi, Behzad Davarnia, Pooneh Nikuei, Morteza Oladnabi, Akbar Mohammadzadeh, Elham Zohrehvand, Azim Nejatizadeh, Mohammad Shekari, Maryam Bagherzadeh, Ehsan Shamsi Gooshki, Stefan T. Börno, Bernd Timmermann, Ali Akbar Haghdoost, Reza Najafipour, Hamid Reza Khorram Khorshid, Kimia Kahrizi, Reza Malekzadeh, Mohammad R. Akbari, Hossein Najmabadi,
Tópico(s)Genetic Associations and Epidemiology
ResumoHuman MutationVolume 40, Issue 11 p. 1968-1984 DATABASES Iranome: A catalog of genomic variations in the Iranian population Zohreh Fattahi, Zohreh Fattahi Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran Kariminejad–Najmabadi Pathology & Genetics Center, Tehran, IranSearch for more papers by this authorMaryam Beheshtian, Maryam Beheshtian Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran Kariminejad–Najmabadi Pathology & Genetics Center, Tehran, IranSearch for more papers by this authorMarzieh Mohseni, Marzieh Mohseni Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran Kariminejad–Najmabadi Pathology & Genetics Center, Tehran, IranSearch for more papers by this authorHossein Poustchi, Hossein Poustchi Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, IranSearch for more papers by this authorErin Sellars, Erin Sellars Women's College Research Institute, University of Toronto, Toronto, Ontario, CanadaSearch for more papers by this authorSayyed Hossein Nezhadi, Sayyed Hossein Nezhadi Department of Computer Science, University of Toronto, Toronto, Ontario, CanadaSearch for more papers by this authorAmir Amini, Amir Amini Information Technology Office, University of Social Welfare and Rehabilitation Sciences, Tehran, IranSearch for more papers by this authorSanaz Arzhangi, Sanaz Arzhangi Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, IranSearch for more papers by this authorKhadijeh Jalalvand, Khadijeh Jalalvand Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, IranSearch for more papers by this authorPeyman Jamali, Peyman Jamali Shahrood Genetic Counseling Center, Welfare Office, Semnan, IranSearch for more papers by this authorZahra Mohammadi, Zahra Mohammadi Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, IranSearch for more papers by this authorBehzad Davarnia, Behzad Davarnia Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, IranSearch for more papers by this authorPooneh Nikuei, Pooneh Nikuei Molecular Medicine Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, IranSearch for more papers by this authorMorteza Oladnabi, Morteza Oladnabi Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, IranSearch for more papers by this authorAkbar Mohammadzadeh, Akbar Mohammadzadeh Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, IranSearch for more papers by this authorElham Zohrehvand, Elham Zohrehvand Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, IranSearch for more papers by this authorAzim Nejatizadeh, Azim Nejatizadeh Molecular Medicine Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, IranSearch for more papers by this authorMohammad Shekari, Mohammad Shekari Molecular Medicine Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, IranSearch for more papers by this authorMaryam Bagherzadeh, Maryam Bagherzadeh Women's College Research Institute, University of Toronto, Toronto, Ontario, CanadaSearch for more papers by this authorEhsan Shamsi-Gooshki, Ehsan Shamsi-Gooshki Medical Ethics and History of Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran Department of Medical Ethics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, IranSearch for more papers by this authorStefan Börno, Stefan Börno Max Planck Institute for Molecular Genetics, Berlin, GermanySearch for more papers by this authorBernd Timmermann, Bernd Timmermann Max Planck Institute for Molecular Genetics, Berlin, GermanySearch for more papers by this authorAliakbar Haghdoost, Aliakbar Haghdoost Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran Regional Knowledge Hub, and WHO Collaborating Centre for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, IranSearch for more papers by this authorReza Najafipour, Reza Najafipour Cellular and Molecular Research Centre, Qazvin University of Medical Sciences, Qazvin, IranSearch for more papers by this authorHamid Reza Khorram Khorshid, Hamid Reza Khorram Khorshid Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, IranSearch for more papers by this authorKimia Kahrizi, Kimia Kahrizi Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, IranSearch for more papers by this authorReza Malekzadeh, Reza Malekzadeh Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, IranSearch for more papers by this authorMohammad R. Akbari, Corresponding Author Mohammad R. Akbari mohammad.akbari@utoronto.ca Women's College Research Institute, University of Toronto, Toronto, Ontario, Canada Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada Correspondence Mohammad R. Akbari, Women's College Hospital, University of Toronto, 76 Grenville Street, Room 6421, M5S 1B2 Toronto, Ontario, Canada. Email: mohammad.akbari@utoronto.ca Hossein Najmabadi, Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Daneshjoo Blvd, Koodakyar St., Evin, Tehran 1985713834, Iran. Email: hnajm12@yahoo.comSearch for more papers by this authorHossein Najmabadi, Corresponding Author Hossein Najmabadi hnajm12@yahoo.com orcid.org/0000-0002-6084-7778 Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran Kariminejad–Najmabadi Pathology & Genetics Center, Tehran, Iran Correspondence Mohammad R. Akbari, Women's College Hospital, University of Toronto, 76 Grenville Street, Room 6421, M5S 1B2 Toronto, Ontario, Canada. Email: mohammad.akbari@utoronto.ca Hossein Najmabadi, Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Daneshjoo Blvd, Koodakyar St., Evin, Tehran 1985713834, Iran. Email: hnajm12@yahoo.comSearch for more papers by this author Zohreh Fattahi, Zohreh Fattahi Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran Kariminejad–Najmabadi Pathology & Genetics Center, Tehran, IranSearch for more papers by this authorMaryam Beheshtian, Maryam Beheshtian Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran Kariminejad–Najmabadi Pathology & Genetics Center, Tehran, IranSearch for more papers by this authorMarzieh Mohseni, Marzieh Mohseni Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran Kariminejad–Najmabadi Pathology & Genetics Center, Tehran, IranSearch for more papers by this authorHossein Poustchi, Hossein Poustchi Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, IranSearch for more papers by this authorErin Sellars, Erin Sellars Women's College Research Institute, University of Toronto, Toronto, Ontario, CanadaSearch for more papers by this authorSayyed Hossein Nezhadi, Sayyed Hossein Nezhadi Department of Computer Science, University of Toronto, Toronto, Ontario, CanadaSearch for more papers by this authorAmir Amini, Amir Amini Information Technology Office, University of Social Welfare and Rehabilitation Sciences, Tehran, IranSearch for more papers by this authorSanaz Arzhangi, Sanaz Arzhangi Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, IranSearch for more papers by this authorKhadijeh Jalalvand, Khadijeh Jalalvand Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, IranSearch for more papers by this authorPeyman Jamali, Peyman Jamali Shahrood Genetic Counseling Center, Welfare Office, Semnan, IranSearch for more papers by this authorZahra Mohammadi, Zahra Mohammadi Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, IranSearch for more papers by this authorBehzad Davarnia, Behzad Davarnia Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, IranSearch for more papers by this authorPooneh Nikuei, Pooneh Nikuei Molecular Medicine Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, IranSearch for more papers by this authorMorteza Oladnabi, Morteza Oladnabi Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, IranSearch for more papers by this authorAkbar Mohammadzadeh, Akbar Mohammadzadeh Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, IranSearch for more papers by this authorElham Zohrehvand, Elham Zohrehvand Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, IranSearch for more papers by this authorAzim Nejatizadeh, Azim Nejatizadeh Molecular Medicine Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, IranSearch for more papers by this authorMohammad Shekari, Mohammad Shekari Molecular Medicine Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, IranSearch for more papers by this authorMaryam Bagherzadeh, Maryam Bagherzadeh Women's College Research Institute, University of Toronto, Toronto, Ontario, CanadaSearch for more papers by this authorEhsan Shamsi-Gooshki, Ehsan Shamsi-Gooshki Medical Ethics and History of Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran Department of Medical Ethics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, IranSearch for more papers by this authorStefan Börno, Stefan Börno Max Planck Institute for Molecular Genetics, Berlin, GermanySearch for more papers by this authorBernd Timmermann, Bernd Timmermann Max Planck Institute for Molecular Genetics, Berlin, GermanySearch for more papers by this authorAliakbar Haghdoost, Aliakbar Haghdoost Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran Regional Knowledge Hub, and WHO Collaborating Centre for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, IranSearch for more papers by this authorReza Najafipour, Reza Najafipour Cellular and Molecular Research Centre, Qazvin University of Medical Sciences, Qazvin, IranSearch for more papers by this authorHamid Reza Khorram Khorshid, Hamid Reza Khorram Khorshid Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, IranSearch for more papers by this authorKimia Kahrizi, Kimia Kahrizi Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, IranSearch for more papers by this authorReza Malekzadeh, Reza Malekzadeh Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, IranSearch for more papers by this authorMohammad R. Akbari, Corresponding Author Mohammad R. Akbari mohammad.akbari@utoronto.ca Women's College Research Institute, University of Toronto, Toronto, Ontario, Canada Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada Correspondence Mohammad R. Akbari, Women's College Hospital, University of Toronto, 76 Grenville Street, Room 6421, M5S 1B2 Toronto, Ontario, Canada. Email: mohammad.akbari@utoronto.ca Hossein Najmabadi, Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Daneshjoo Blvd, Koodakyar St., Evin, Tehran 1985713834, Iran. Email: hnajm12@yahoo.comSearch for more papers by this authorHossein Najmabadi, Corresponding Author Hossein Najmabadi hnajm12@yahoo.com orcid.org/0000-0002-6084-7778 Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran Kariminejad–Najmabadi Pathology & Genetics Center, Tehran, Iran Correspondence Mohammad R. Akbari, Women's College Hospital, University of Toronto, 76 Grenville Street, Room 6421, M5S 1B2 Toronto, Ontario, Canada. Email: mohammad.akbari@utoronto.ca Hossein Najmabadi, Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Daneshjoo Blvd, Koodakyar St., Evin, Tehran 1985713834, Iran. Email: hnajm12@yahoo.comSearch for more papers by this author First published: 25 July 2019 https://doi.org/10.1002/humu.23880Citations: 79Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Considering the application of human genome variation databases in precision medicine, population-specific genome projects are continuously being developed. However, the Middle Eastern population is underrepresented in current databases. Accordingly, we established Iranome database (www.iranome.com) by performing whole exome sequencing on 800 individuals from eight major Iranian ethnic groups representing the second largest population of Middle East. We identified 1,575,702 variants of which 308,311 were novel (19.6%). Also, by presenting higher frequency for 37,384 novel or known rare variants, Iranome database can improve the power of molecular diagnosis. Moreover, attainable clinical information makes this database a good resource for classifying pathogenicity of rare variants. Principal components analysis indicated that, apart from Iranian-Baluchs, Iranian-Turkmen, and Iranian-Persian Gulf Islanders, who form their own clusters, rest of the population were genetically linked, forming a super-population. Furthermore, only 0.6% of novel variants showed counterparts in “Greater Middle East Variome Project”, emphasizing the value of Iranome at national level by releasing a comprehensive catalog of Iranian genomic variations and also filling another gap in the catalog of human genome variations at international level. We introduce Iranome as a resource which may also be applicable in other countries located in neighboring regions historically called Greater Iran (Persia). CONFLICT OF INTEREST The authors declare that there is no conflict of interest. Citing Literature Supporting Information Filename Description humu23880-sup-0001-Supp._table_1.xlsx32.5 KB Supporting information humu23880-sup-0002-Supp._table_2.xlsx389.5 KB Supporting information humu23880-sup-0003-Supp_Mat.docx793.9 KB Supporting information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume40, Issue11November 2019Pages 1968-1984 RelatedInformation
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