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Carboxyl Transfer of α-Keto Acids toward Oxazolidinones via Decarboxylation/Fixation of Liberated CO 2

2019; American Chemical Society; Volume: 84; Issue: 16 Linguagem: Inglês

10.1021/acs.joc.9b01547

1520-6904

Huiqiong Li, Huangdi Feng, Fang Wang, Liliang Huang,

Asymmetric Hydrogenation and Catalysis

A novel strategy for the direct carboxyl transfer involving a decarboxylative A3 reaction of α-keto acids, primary amines, and alkynes has been developed under a Cu(I)/Cu(II) binary catalysis system. This multicomponent reaction provides a facile and efficient approach for the production of a diverse range of 2-oxazolidinones in moderate to excellent yields through a one-pot CO2 elimination-fixation procedure. The conciseness of the "CO2 recycling" process makes this ideal synthesis superior over classical CO2 utilization.