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Non-motor symptoms burden, mood, and gait problems are the most significant factors contributing to a poor quality of life in non-demented Parkinson's disease patients: Results from the COPPADIS Study Cohort

2019; Elsevier BV; Volume: 66; Linguagem: Inglês

10.1016/j.parkreldis.2019.07.031

1873-5126

Diego Santos‐García, T. de Deus Fonticoba, E. Suárez Castro, Carmen Borrué, M. Mata, Berta Solano Vila, A. Cots Foraster, María Álvarez Saúco, A. B. Rodríguez Pérez, Lydia Vela, Yolanda Macías, Sonia Escalante, Patricia Esteve, Sílvia Reverté‐Villarroya, Esther Cubo, Erik Jesús Huánuco Casas, S. Arnáiz, Francisco Carrillo Padilla, Mercedes Pueyo Morlans, Pablo Mir, Pablo Martínez‐Martin, A. D. Adarmes, Marta Almería, G. Alonso Losada, A. Alonso Cánovas, Fernando Alonso‐Frech, Sonia López Arribas, A. Ascunde Vidondo, M. Aquilar, Marcos Ávila, N. Bernardo Lambrich, H. Bejr-Kasem, Marta Blázquez Estrada, M. Botí, Carolina Cabello, Iria Cabo, Núria Caballol, A. Cámara Lorenzo, F. Carrillo, M.J. Catalán, Pedro Clavero, A. Cortina Fernández, A. Crespo Cuevas, Oriol de Fábregues, Mónica Díez-Fairén, Elena Erro, E. Estelrich Peyret, N. Fernández Guillán, P. Gámez, M. Gallego, Juan García Caldentey, Cristina Campos, J M García-Moreno, Itziar Gastón, M. P. Gómez Garre, J. González Aloy, Isabel González Aramburu, Jessica González Ardura, B. González García, M. J. González Palmás, G. R. González Toledo, Adam Diaz, M. Grau Solá, G. Guardia, Jorge Hernández‐Vara, Andrea Horta‐Barba, Jon Infante, Silvia Jesús, Jaime Kulisevsky, Mónica Kurtis, Carmen M. Labandeira, M. A. Labrador, Francisco Agramunt Lacruz, M. Lage Castro, I. Legarda, Núria López Ariztegui, L. M. López Díaz, Lydia López Manzanares, B. López Seoane, G. Martí Andrés, Marı́a José Martı́, Juan Carlos Martínez‐Castrillo, Darrian McAfee, M. T. Meitín, Manuel Menéndez‐González, C. Méndez del Barrio, J. Miranda Santiago, María Isabel Morales‐Casado, Antonio Moreno Diéguez, Víctor Nogueira, A. Novo Amado, S. Novo Ponte, Carlos Ordás, Javier Pagonabarraga, Isabel Pareés, Berta Pascual‐Sedano, Pau Pástor, A. Pérez Fuertes, R. Pérez Noguera, Ll Planellas, Josep Pol-Fuster, M. A. Prats, C. Prieto Jurczynska, Víctor Puente, N. Redondo Rafales, Lorena Méndez, F Pérez Roldán, M. Ruíz De Arcos, Javier Ruiz‐Martínez, Pilar Sánchez Alonso, M. Sánchez-Carpintero, G. Sánchez Díez, Ángel Rodríguez, Pilar Santacruz, J. C. Segundo Rodríguez, Manuel Seijo, A. Serarols, M. Sierra Peña, Juan Pablo Tartari, Luis Vargas, R. Vázquez Gómez, Clara Villanueva, Bárbara Vives, María Dolores Castillo Villar,

Cerebral Palsy and Movement Disorders

Objective To identify factors related to a poor health-related and global quality of life (QoL) in a cohort of non-demented Parkinson's disease (PD) patients and compare to a control group. Methods The data correspond to the baseline evaluation of the COPPADIS-2015 Study, an observational, 5-year follow-up, multicenter, evaluation study. Three instruments were used to assess QoL: (1) the 39-item Parkinson's disease Questionnaire (PDQ-39), (2) a subjective rating of global QoL (PQ-10), and (3) the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Multiple linear regression methods were used to evaluate the direct impact of different variables on these QoL measures. Results QoL was worse in PD patients (n = 692; 62.6 ± 8.9 years old, 60.3% males) than controls (n = 206; 61 ± 8.3 years old, 49.5% males): PDQ-39, 17.1 ± 13.5 vs 4.4 ± 6.3 (p < 0.0001); PQ-10, 7.3 ± 1.6 vs 8.1 ± 1.2 (p < 0.0001); EUROHIS-QOL8, 3.8 ± 0.6 vs 4.2 ± 0.5 (p < 0.0001). A high correlation was observed between PDQ-39 and Non-Motor Symptoms Scale (NMSS) (r = 0.72; p < 0.0001), and PDQ-39 and Beck Depression Inventory-II (BDI-II) (r = 0.65; p < 0.0001). For health-related QoL (PDQ-39), non-motor symptoms burden (NMSS), mood (BDI-II), and gait problems (Freezing Of Gait Questionnaire [FOGQ]) provided the highest contribution to the model (β = 0.32, 0.28, and 0.27, respectively; p < 0.0001); whereas mood and gait problems contributed the most to global QoL (PQ-10, β = -0.46 and −0.21, respectively; EUROHIS-QOL8, β = -0.44 and −0.23, respectively). Conclusions QoL is worse in PD patients than in controls. Mood, non-motor symptoms burden, and gait problems seem to be the most relevant factors affecting health-related and global perceived QoL in non-demented PD patients.