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Clinical efficacy of mannitol (10%) with glycerine (10%) versus mannitol (20%) in cerebral oedema

2019; MedCrave Group; Volume: 9; Issue: 4 Linguagem: Inglês

10.15406/jnsk.2019.09.00380

2373-6410

Avinash Shankar,

Neurological Disorders and Treatments

Cerebral oedema is a common cause of unconsciousness and various manifestation in Cerebrovascular accident, head injury, convulsive disorder and encephalitis either due to infection or toxin due to failure of energy dependant Sodium Potassium ATPase pump resulting accumulation of sodium and water in addition release of free radicals and proteases due to activation of microglial cells disrupts cell membrane and capillaries.Objective of the study: Comparative assessment of clinical efficacy of Mannitol 10% with Glycerol 10% versus Mannitol 20% in cerebral oedema of varied origin. Material & method:In this study 1171 patients of cerebral oedema of various aetiology attending Medical Emergency of RA Hospital & Research Centre, Warisaliganj (Nawada) Bihar been selected for comparative evaluation of Mannitol (10%) with Glycerol (10%) versus Mannitol (20%) intravenously to adjudge the clinical efficacy and safety profile.Result: Patients of Group A taking Mannitol (10%) with Glycerol (10%) had grade I clinical response in % 9584/586) without any adversity, residual neurological deficit or mortality and morbidity while patients of Group B on Mannitol (20%) only % (108/585) with 92 mortality and morbidity in 279 cases.