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IBD-Associated Dysplastic Lesions Show More Chromosomal Instability Than Sporadic Adenomas

2019; Oxford University Press; Volume: 26; Issue: 2 Linguagem: Inglês

10.1093/ibd/izz171

1536-4844

Linda K Wanders, Martijn Cordes, Quirinus J.M. Voorham, Daoud Sie, Sara de Vries, Geert R. DʼHaens, Nanne K.H. de Boer, Bauke Ylstra, Nicole C.T. van Grieken, Gerrit A. Meijer, Evelien Dekker, Beatriz Carvalho,

Chronic Lymphocytic Leukemia Research

Inflammatory bowel disease (IBD) patients are at increased risk of developing colorectal cancer. However, histologically, it is challenging to distinguish between IBD-associated dysplasia from sporadic adenomas. We have molecularly characterized these precursor lesions and show that IBD-associated dysplasia lesions are genomically much more unstable.