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Molecular Characterization and Clinical Outcomes of Primary Gleason Pattern 5 Prostate Cancer After Radical Prostatectomy

2019; Lippincott Williams & Wilkins; Issue: 3 Linguagem: Inglês

10.1200/po.19.00081

2473-4284

Pedro Isaacsson Velho, David Lim, Hao Wang, Jong Chul Park, Harsimar Kaur, Fawaz Almutairi, Michael A. Carducci, Samuel R. Denmeade, Mark C. Markowski, William B. Isaacs, Emmanuel S. Antonarakis, Colin C. Pritchard, Mario A. Eisenberger, Tamara L. Lotan,

Hormonal and reproductive studies

Very high-risk prostate cancer (PC) is associated with poor response to local and systemic treatments; however, few cases have been molecularly profiled. We studied clinical outcomes and molecular profiles of patients with clinically localized primary Gleason pattern 5 PC.