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High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis

2019; Lippincott Williams & Wilkins; Volume: 93; Issue: 17 Linguagem: Inglês

10.1212/wnl.0000000000008081

1526-632X

Suzanne E. Schindler, James G. Bollinger, Vitaliy Ovod, Kwasi G. Mawuenyega, Yan Li, Brian A. Gordon, David M. Holtzman, John C. Morris, Tammie L.S. Benzinger, Chengjie Xiong, Anne M. Fagan, Randall J. Bateman,

Dementia and Cognitive Impairment Research

We examined whether plasma β-amyloid (Aβ)42/Aβ40, as measured by a high-precision assay, accurately diagnosed brain amyloidosis using amyloid PET or CSF p-tau181/Aβ42 as reference standards.