Disruption Of The Biological Clock Affects Immune Homeostasis And Aggravates Atherosclerosis Development
2019; Elsevier BV; Volume: 287; Linguagem: Inglês
10.1016/j.atherosclerosis.2019.06.044
ISSN1879-1484
AutoresMaaike Schilperoort, René van den Berg, Linda W. M. van Kerkhof, Martijn E.T. Dollé, Debbie van Baarle, Teun Guichelaar, Nicole C. Smits, Marcel de Vries, Nienke R. Biermasz, Sander Kooijman, Patrick C.N. Rensen,
Tópico(s)Circadian rhythm and melatonin
ResumoBackground and Aims: Disruption of circadian (i.e. 24 h) rhythm by means of shift work has been associated with obesity, dyslipidemia and cardiovascular disease in humans. However, causality and underlying mechanisms have not yet been established. The aim of this study was to investigate in mice whether mimicking shift work by chronically alternating light cycles directly affects atherosclerosis development, and elucidate underlying mechanisms.
Referência(s)